Ditch the suit

There wasn't much Screwball could do while she was stuck to the wall, but she realized only her jumpsuit was webbed to it. Seeing as Spider-Man was closing in, she made a desperate choice and pulled herself up, wriggling her arms out of the sleeves so she could pull the rest of her body out of her jumpsuit, landing on the cold concrete roof completely naked, save for her shoes, helmet and sunglasses.

She scrambled to her feet as soon as she was free and began running again, using whatever cover she could to both conceal her bare body and stay out of sight so she could make her getaway. However, even if this display caught Peter off-guard, he was still determined to bring her in. While she did put some distance between them, he still hadn't lost visual contact. Realizing she was shielding herself from sight with the rooftops, Peter decided to use that to his advantage.

Using his web-swinging skills, he effectively "steered" the nude criminal in a direction that wound up with her facing the edge of Times Square, catching her between the friendly neighborhood Spider-Man and the bustling city below. There were balconies and awnings she could use to run along the buildings, but those potentially exposed her more. But then again, she could just give up... as if!