Nosferatu

The Nosferatu seem like they might be the worst clan in Vampire; they’re all ugly as hell (think Count Orlock from Nosferatu, natch), they can’t hide among humanity at all, and they generally hide in sewers. Moreover, they don’t really have any benefits to balance all the crap life (er, unlife (well, the Vampire RPG)) has dumped on them.

Sure, the Nosferatu are supposed to be really good at spying thanks to their Obfuscate ability, but Malkaians have Obfuscate too and they don’t make people want to throw up when they see them.
Basically, the only reason the Nosferatu aren’t on the bottom of the list is that there a power in being a monster that looks truly monstrous — a dignity in saying “fuck it” to the rest of Vampire society/the game and choosing to wear your hideous curse on your sleeve. And face. And everything else.