Other options

"What else can we do?" asked Chastity.

"Well," said Emily. "We can make her gain a ton of weight and either have her gain weight all over her body or concentrate it below the waist. Instead of all her her hair falling out, we can make her extra-hairy by over stimulating the hair follicles on her upper lip, her eyebrows, her pubic region, butt, chest, and armpits. We can make her totally incontinent. Lower her IQ and ramp up her sex drive so she becomes a dimwitted slut. Any of those sound good?"

"Yeah, but I want her to know how humiliating this is for her, so that last one may not work."

"Makes sense. We can have her act like a dimwitted slut but not be able to do anything about it."

"Interesting."